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Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review

Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2, Pages 104-113 doi: 10.15302/J-FASE-2014003

Abstract: The reprogramming of the somatic nucleus from its original cellular state to a totipotent state is essentialfor term development after somatic cell nuclear transfer.nuclear-associated factors contained within oocytes are critical for normal fertilization by sperm or for somaticcell nuclear reprogramming.The chromatin of somatic nuclei can be reprogrammed by factors in the egg cytoplasm whose natural function

Keywords： nuclear reprogramming somatic cell transcription factors transcriptomics

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Factors influencing the somatic cell nuclear transfer efficiency in pigs

Yong JIN, Manling ZHANG, Xinrong JU, Shuang LIANG, Qiang XIONG, Lihua ZHAO, Xiaowei NIE, Daorong HOU, Qiang LIU, Junzheng WANG, Chenyu WANG, Xiaokang LI, Lining ZHANG, Xiaorui LIU, Ying WANG, Haiyuan YANG, Yifan DAI, Rongfeng LI

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 73-80 doi: 10.15302/J-FASE-2018220

Abstract: The results demonstrated that cells at high confluence (>90%) used as donor cell resulted in higherThe number of blastocysts transferred by somatic cell nuclear transfer (SCNT) did not significantly affectfrom culture 5 d after SCNT achieved a significantly higher pregnancy rate compared with one to two cell

Keywords： blastocyst donor cell estrus synchronization pregnancy rate pig cloning somatic cell nuclear transfer

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Factors affecting early embryonic development in cattle: relevance for bovine cloning

Yanna DANG, Kun ZHANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 33-41 doi: 10.15302/J-FASE-2018228

Abstract: Meanwhile, early embryo development is significant for somatic cell nuclear transfer in cattle as a large

Keywords： bovine cloning embryo development somatic cell nuclear transfer X-inactive specific transcript

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The ecological adaptability of cloned sheep to free-grazing in the Tengger Desert of Inner Mongolia, China

Xinxin LI,Huijuan WANG,Guanghua SU,Zhuying WEI,Chunling BAI,Wuni-MENGHE,Yanhui HOU,Changqing YU,Shorgan BOU,Guangpeng LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3, Pages 191-200 doi: 10.15302/J-FASE-2014029

Abstract: Since the birth of the first cloned sheep, somatic cell nuclear transfer technology has been successfully

Keywords： somatic cell nuclear transfer free-grazing synchronization Dorper sheep cloned animal ecology

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Generation and repair of AID-initiated DNA lesions in B lymphocytes

Zhangguo Chen,Jing H. Wang

Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 201-216 doi: 10.1007/s11684-014-0324-4

Abstract: In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination

Keywords： class switch recombination somatic hypermutation activation-induced deaminase DNA repair genomic instability

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Induced pluripotent stem cells (IPS): current situation and prospect

Han Weidong,Zhao Yali,Fu Xiaobing

Strategic Study of CAE 2009, Volume 11, Issue 5, Pages 81-87

Abstract:

Differentiated somatic cells can be reprogrammed into induced pluripotentUndoubtedly, iPS-cell technology is a great breakthrough of stem cell research field in recent years.However, the present development of pluripotent cells from individual somatic cells just opened up aas a clinically reliable cell source.Here, the iPS cell research advances in recent years were reviewed and the feasible applications of iPS-cell

Keywords： somatic cells reprogramming iPS cells

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Transcriptome resources and genome-wide marker development for Japanese larch (

Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1, Pages 77-84 doi: 10.15302/J-FASE-2014010

Abstract: published Roche 454 sequencing reads and the expressed sequence tags (both mainly from embryogenic cellwhich we annotated 79182 to support investigations of the molecular basis of tree aging and adaption, somatic

Keywords： Larix transcriptome age wood formation somatic embryogenesis molecular marker

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Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1, Pages 90-98 doi: 10.1007/s11705-015-1550-2

Abstract: The well-designed microscale intermediary is also ideal for the study of cell biology.Particularly, microfluidic chip is helpful for better understanding cell-cell interactions.

Keywords： microfluidic chip co-culture cell-cell interactions review

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in

Frontiers of Medicine Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cellMNDCMs having interactions with macrophages and non-proliferative MNDCMs (non-pMNDCMs) with minimal cell–cellThese MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data.In conclusion, a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled, highlighting

Keywords： mononuclear diploid cardiomyocytes cell–cell communication cardiac fibroblast single-cell RNA sequencing

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Deubiquitinases as pivotal regulators of T cell functions

Xiao-Dong Yang, Shao-Cong Sun

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 451-462 doi: 10.1007/s11684-018-0651-y

Abstract: Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activationAn emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversibleIt is now well recognized that DUBs are crucial regulators of T cell responses and serve as potential

Keywords： deubiquitinase ubiquitination T cell activation T cell differentiation T cell tolerance

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Cell surface protein engineering for high-performance whole-cell catalysts

Hajime Nakatani,Katsutoshi Hori

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 46-57 doi: 10.1007/s11705-017-1609-3

Abstract: Cell surface protein engineering facilitated by accumulation of information on genome and protein structureinvolves heterologous production and modification of cell surface proteins using genetic engineering, and is important for the development of high-performance whole-cell catalysts.In this field, cell surface display is a major technology by exposing target proteins, such as enzymes, on the cell surface using a carrier protein.

Keywords： cell surface engineering surface display whole-cell catalysts bioprocess

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Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 40-44 doi: 10.1007/s11684-011-0108-z

Abstract: Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichMany regulatory factors are involved in the stem cell-based repair process, including stem cell nichesHere we briefly review the role of stem cell niches and endogenous electric fields in tissue repair,and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.

Keywords： stem cell stem cell niche electric field tissue repair

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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 783-804 doi: 10.1007/s11684-021-0904-z

Abstract: Chimeric antigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematologicalIn this review, through a representative case study, we summarize the current experience of CAR T-cellthe causative mechanisms of therapy resistance, and new strategies to improve the efficacy of CAR T-cell

Keywords： CAR T cells hematological malignancies review

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial

Keywords： ALDOB kidney cancer cell proliferation

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The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 348-355 doi: 10.1007/s11684-011-0150-x

Abstract: notwithstanding, hundreds of companies and private clinics around the world now sell putative stem cellIn this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with

Keywords： stem cell tourism medical ethics stem cell policy and regulation alternative medicine